Precision-CARRS

OVERVIEW OF PRECISION-CARRS

The overarching goal of P-CARRS is to transform the current cardiovascular disease (CVD) risk prediction paradigm that is based on conventional, imprecise atherosclerotic cardiovascular disease (ASCVD) risk factors to personalized and precise disease prediction and early-stage detection to promote cardiovascular health.

The objectives for Precision-CARRS are to:

  • Estimate the prevalence, incidence, and predictors of subclinical and clinical vascular and myocardial disease, with exploration of pathophysiologic pathways.

  • Investigate the role of environmental exposures (air pollution/built environment) on the development of subclinical and clinical vascular and myocardial disease.

  • Investigate multi-omic determinants of subclinical and clinical vascular and myocardial disease.

  • Investigate spousal and behavioral influences on subclinical and clinical vascular and myocardial disease.

Precision-CARRS will unravel the natural history, pathophysiology, and causal factors of ASCVD and myocardial disease and pave the way for precision CVD diagnostics, prevention, and care for South Asians, who account for 20% of humanity, are a rapidly growing but understudied US population, and are at high CVD and diabetes risk even at younger ages, despite having a thin body phenotype.

Please check out our latest Precision-CARRS Newsletter.